Zosyn Injection 4.5 gm (PIPERACILLIN-4GM + TAZOBACTAM-500MG)
| COUNTRY OF ORIGIN | India |
|---|---|
| DOSAGE FORM | Injection |
| GENERIC NAME | PIPERACILLIN + TAZOBACTAM |
| INDICATION | Bacterial infections |
| PACKAGING | 4.5 gm Injection in 1 Vial |
| MANUFACTURER | Pfizer Ltd |
| COMPOSITION | PIPERACILLIN-4GM + TAZOBACTAM-500MG |
Zosyn Injection 4.5 gm belongs to the ‘Antibiotics’ class of drugs, primarily used to treat bacterial infections. It is used to treat various hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections (like diabetic foot infections) and uterine infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly.
Zosyn Injection 4.5 gm contains two medicines, namely: Piperacillin (Penicillin antibiotic) and Tazobactam (beta-lactamase inhibitor). Piperacillin belongs to the class of ‘Penicillin antibiotics.’ It has bactericidal (ability to kill bacteria) activity against gram-positive and gram-negative aerobic (requires oxygen to survive) and anaerobic (survives with little or no oxygen) bacteria. Piperacillin acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor. Beta-lactamases are the enzymes produced by bacteria to gain multi-resistance to β-lactam antibiotics, such as penicillins and cephalosporins. Tazobactam prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. In Zosyn Injection 4.5 gm, Tazobactam works by preventing bacteria from destroying Piperacillin.
Zosyn Injection 4.5 gm is available in the form of intravenous injection. Like all medicines, Zosyn Injection 4.5 gm also causes side effects, although not everybody gets them. Common side effects of Zosyn Injection 4.5 gm include nausea, constipation, diarrhoea, headache, and trouble sleeping. If any of these effects persist or worsen, seek medical advice promptly.
Brief your medical history to the doctor if you have any allergic reactions to antibiotics. Please inform your doctor if you have any liver, kidney diseases, bleeding disorders, and fits. Do not use Zosyn Injection 4.5 gm while having vaccinations with live bacterial vaccines (typhoid vaccine) since Zosyn Injection 4.5 gm may affect vaccines’ activity. Zosyn Injection 4.5 gm should be used during pregnancy only if the doctor advised you. It is also excreted into breast milk in small amounts. Hence, it is recommended to consult your doctor if you are pregnant or breastfeeding before taking Zosyn Injection 4.5 gm.
Uses of Zosyn Injection 4.5 gm
Bacterial infections, hospital-acquired and ventilator-associated pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, and uterine infections.
Medicinal Benefits
Zosyn Injection 4.5 gm contains two medicines, namely: Piperacillin and Tazobactam. Piperacillin is a Penicillin antibiotic. It acts by binding to the penicillin-binding proteins (PBPs) inside the bacterial cell wall and inhibits its cell wall synthesis. Tazobactam is a beta-lactamase inhibitor that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. In Zosyn Injection 4.5 gm, Tazobactam works by preventing bacteria from destroying Piperacillin. Thus, Zosyn Injection 4.5 gm helps treat various bacterial infections of the stomach, lungs, skin and uterus.
Directions for Use
Storage
Side Effects of Zosyn Injection 4.5 gm
- Nausea
- Constipation
- Diarrhoea
- Headache
- Trouble sleeping
In-Depth Precautions and Warning
Drug Warnings
If you have a history of any cystic fibrosis (damaged lungs and digestive system), kidney disease, fits, colitis (inflammation of the colon), bleeding disorders, heart or liver diseases, please inform your doctor before starting Zosyn Injection 4.5 gm. Please tell your doctor if you are undergoing dialysis treatment since Penicillin antibiotics like Piperacillin are removed by haemodialysis. Your doctor may schedule the dosage after dialysis. Clostridium difficile associated diarrhoea (CDAD) is reported during usage of antibiotics like Zosyn Injection 4.5 gm. Therefore, please undergo an examination to rule out the chances of CDAD if you experience diarrhoea following Zosyn Injection 4.5 gm therapy.
Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Zosyn Injection 4.5 gm may affect vaccines’ activity. Zosyn Injection 4.5 gm should be used with caution during pregnancy since it crosses the placenta in humans. Zosyn Injection 4.5 gm is also excreted into breast milk. Please seek medical advice if you are pregnant or breastfeeding before taking Zosyn Injection 4.5 gm. Patients aged above 65 years are not at an increased risk of having side effects. However, the dosage should be adjusted if the patient has a history of renal impairment. Sometimes, antibiotic medications can cause antibiotic resistance. In such cases, your doctor may prescribe other antibiotics, you are not resistant.
Drug Interactions
Drug-Drug Interaction: Zosyn Injection 4.5 gm may interact with anticoagulants (heparin), anti-cancer drugs (methotrexate), antibiotics (tobramycin, vancomycin), gout medicines (probenecid), and anaesthetic drugs (vecuronium).
Drug-Food Interaction: Avoid alcohol consumption while taking Zosyn Injection 4.5 gm to prevent unpleasant side-effects, such as nausea and vomiting.
Drug-Disease Interaction: Before taking Zosyn Injection 4.5 gm, let your doctor know if you have cystic fibrosis, kidney disease, fits, colitis, bleeding disorders, heart or liver diseases, and are undergoing dialysis treatment.
Safety Advice
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ALCOHOL
Avoid alcohol consumption while taking Zosyn Injection 4.5 gm to prevent unpleasant side-effects, such as nausea and vomiting.
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PREGNANCY
Zosyn Injection should be used with caution during pregnancy since it crosses the placenta in humans. Please consult your doctor before taking Zosyn Injection if you are pregnant or planning to conceive.
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BREAST FEEDING
There is limited data on how Zosyn Injection affects breastfed infants. Zosyn Injection is excreted into breast milk. Please consult your doctor before taking Zosyn Injection if you are breastfeeding.
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DRIVING
It is unknown whether Zosyn Injection affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed. If you experience dizziness or fatigue after taking Zosyn Injection, do not drive or operate any machinery.
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LIVER
Let your doctor know if you have any history of liver diseases before taking Zosyn Injection. Your doctor will prescribe Zosyn Injection only if the benefits outweigh the risk.
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KIDNEY
Penicillin antibiotics are easily removed by dialysis. Beta-lactam antibiotics like Tazobactam should be cautiously administered in patients with renal impairment. Prolonged use of Zosyn Injection may cause nephrotoxicity and alterations in renal function, hence please let your doctor know if you have any history of kidney diseases before taking Zosyn Injection. Your doctor will prescribe Zosyn Injection only if the benefits outweigh the risk.
Habit Forming
Diet & Lifestyle Advise
- Include more fibre enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fibre foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet.
- Eating grapefruit during antibiotics treatment can prevent the body from utilizing Zosyn Injection properly. So, avoid intake of grapefruit or grapefruit juice with the antibiotic.
- Avoid intake of alcoholic beverages with Zosyn Injection as it can make you dehydrated and affect your sleep. This can make it more challenging for your body to aid the Zosyn Injection in fighting off infections.
- Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
- Do not walk barefoot at places like gym showers to prevent bacterial infections.
Special Advise
- Renal, hepatic, and blood function tests are advised during prolonged therapy to rule out any toxicity caused due to overdose of Zosyn Injection.
- Clostridium difficile associated diarrhoea (CDAD) is reported during usage of antibiotics like Zosyn Injection. Please see your doctor if you experience prolonged diarrhoea.
- Penicillin antibiotics are easily removed during dialysis, hence let your doctor know if you are undergoing dialysis treatment so that the dose can be scheduled after the dialysis.
- It may also affect urine glucose tests, hence inform your doctor beforehand if you are using Zosyn Injection.
Other Information (ZOS0010)
This item is Not Returnable.
Expires on or after – Sep-2022
Patients Concern
Disease/Condition Glossary
Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria occur in three basic shapes: spherical, rod and spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever and tiredness.
Hospital-acquired pneumonia/ nosocomial pneumonia: It is a lower respiratory infection of the lungs that occurs during a hospital stay.
Ventilator-associated pneumonia: A lung infection occurs in people who are on mechanical ventilation breathing machines in hospitals.
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