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DaciHep Tablets

$59.39 $49.23

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Description

Product Details:

Minimum Order Quantity 3 Bottle
Brand DaciHep
Dose/Strength 60 mg
Packaging Size 28 Tablets

Indication:

  • Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
  • Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
  • These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.
  • Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Mechanism of action:

  • The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b.
  • Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes.
  • We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking.
  • Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV.
  • These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web.
  • Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation.

Side effects:

  • Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
  • Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
  • Many people using this medication do not have serious side effects.
  • Precaution: Before taking daclatasvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
  • This product may contain inactive ingredients, which can cause allergic reactions or other problems.
  • Talk to your pharmacist for more details.

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